Clinically, late-phase pain often becomes dissociated from inflammation and resistant to anti-inflammatory therapies, resembling NPP
Nrf2 activation upregulates a series of genes including those involved in xenobiotic and ROS detoxification in order to resist oxidant and electrophilic environmental stressors [73,74]
Bannon, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States Specialty section: This article was submitted to Cellular Neurophysiology, a section of the journal Frontiers in Cellular Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
acknowledges support from the David and Lucile Packard Foundation, the Camille Dreyfus Teacher-Scholar Program, the Defense Threat Reduction Agency Grants HDTRA1-15-10052, HDTRA-12-11-0038 and HDTRA-12-01-0004, the Army Research Office Grants W911NF-20-1-0195, W911NF-18-1-0200 and W911NF-16-1-0372, the Army Contracting Command Contract W52P1J-21-9-3023 and DARPA Grant W911NF-23-2-0039
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